7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

Base Information

Chemical Name:7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman
CAS No.:1454883-54-5
Molecular Formula:C₂₅H₂₃BrO₅
Molecular Weight:483.359
Hs Code.:

Synonyms:7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

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Chemical Property of 7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

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Technology Process of 7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

There total 6 articles about 7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 889115-21-3
2-{5-bromobenzo[d][1,3]dioxol-6-yl}acetaldehyde

: 64881-05-6
1-<4-(benzyloxy)-3-methoxyphenyl>ethan-2-ol

: 1454883-54-5
7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 18h; Reflux; Dean-Stark;
DOI:10.1016/j.tet.2013.07.095

Reference yield:

: 65340-85-4
benzyl 2-(4-(benzyloxy)-3-methoxyphenyl)acetate

: 1454883-54-5
7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Dean-Stark

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; 2: |Pictet-Spengler Synthesis;
DOI:10.1016/j.tet.2013.07.095

Reference yield:

: 306-08-1
Homovanillic acid

: 1454883-54-5
7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 4 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Dean-Stark

With lithium aluminium tetrahydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; acetonitrile; 3: |Pictet-Spengler Synthesis;
DOI:10.1016/j.tet.2013.07.095