1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

Base Information

Chemical Name:1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene
CAS No.:1454883-55-6
Molecular Formula:C₂₅H₂₂O₅
Molecular Weight:402.447
Hs Code.:

Synonyms:1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

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Chemical Property of 1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

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Technology Process of 1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

There total 4 articles about 1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1454883-54-5
7-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-6-methoxyisochroman

: 1454883-55-6
1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

Guidance literature:: With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In dimethyl sulfoxide; at 140 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.tet.2013.07.095

Reference yield:

: 65340-85-4
benzyl 2-(4-(benzyloxy)-3-methoxyphenyl)acetate

: 1454883-55-6
1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Dean-Stark

3: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate / dimethyl sulfoxide / 0.17 h / 140 °C / Microwave irradiation

With lithium aluminium tetrahydride; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; tricyclohexylphosphine tetrafluoroborate; In tetrahydrofuran; dimethyl sulfoxide; toluene; 2: |Pictet-Spengler Synthesis;
DOI:10.1016/j.tet.2013.07.095

Reference yield:

: 64881-05-6
1-<4-(benzyloxy)-3-methoxyphenyl>ethan-2-ol

: 1454883-55-6
1-(benzyloxy)-2-methoxy-4,5,6a,7-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[de]chromene

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Dean-Stark

2: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate / dimethyl sulfoxide / 0.17 h / 140 °C / Microwave irradiation

With palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; tricyclohexylphosphine tetrafluoroborate; In dimethyl sulfoxide; toluene; 1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.tet.2013.07.095