N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine

Base Information

• Chemical Name: N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine
• CAS No.: 863920-68-7
• Molecular Formula: C₂₀H₂₈N₄O₄S
• Molecular Weight: 420.533

Synonyms:N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine

Chemical Property of N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine

Chemical Property:

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Technology Process of N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine

There total 5 articles about N²-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dihydroxy-6-methyl-3-nitropyridine (4966-90-9) → N2-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N4-(1-propyl-butyl)-pyridine-2,4-diamine (863920-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; 4-dimethylaminopyridine / tetrahydrofuran / 1 h / Heating

2: 1069 g / triethylamine / tetrahydrofuran / Heating

3: phosphorus oxychloride; DMF / acetonitrile / 2 h / 50 °C

4: acetonitrile / 65 °C

With dmap; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm050384+

Reference yield:

benzenesulfonic acid 2-hydroxy-6-methyl-3-nitro-pyridin-4-yl ester (1027728-77-3) → N2-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N4-(1-propyl-butyl)-pyridine-2,4-diamine (863920-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1069 g / triethylamine / tetrahydrofuran / Heating

2: phosphorus oxychloride; DMF / acetonitrile / 2 h / 50 °C

3: acetonitrile / 65 °C

With triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm050384+

Reference yield:

6-methyl-3-nitro-4-(1-propyl-butylamino)pyridin-2-ol (197803-31-9) → N2-(4-methanesulfonyl-phenyl)-6-methyl-3-nitro-N4-(1-propyl-butyl)-pyridine-2,4-diamine (863920-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxychloride; DMF / acetonitrile / 2 h / 50 °C

2: acetonitrile / 65 °C

With N,N-dimethyl-formamide; trichlorophosphate; In acetonitrile;

DOI:10.1021/jm050384+

upstream raw materials:

2-chloro-4-(4-heptyl)amino-6-methyl-3-nitropyridine

4-methanesulfonylphenylamine

benzenesulfonic acid 2-hydroxy-6-methyl-3-nitro-pyridin-4-yl ester

6-methyl-3-nitro-4-(1-propyl-butylamino)pyridin-2-ol

Downstream raw materials:

3-(4-methanesulfonyl-phenyl)-5-methyl-7-(1-propyl-butylamino)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

N²-(4-methanesulfonyl-phenyl)-6-methyl-N⁴-(1-propyl-butyl)-pyridine-2,3,4-triamine

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