1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Base Information

Chemical Name:1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
CAS No.:1379541-15-7
Molecular Formula:C₂₉H₄₂N₈O₃
Molecular Weight:550.704
Hs Code.:

1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Synonyms:1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

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Chemical Property of 1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

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Technology Process of 1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

There total 11 articles about 1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1379541-15-7
1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

1.2: pH 7

2.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

6.1: cyclohexa-1,4-diene; ethanol / palladium 10% on activated carbon / 2 h / 85 °C / Reflux

7.1: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

8.1: acetic acid / 3.25 h / Reflux

9.1: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

10.1: methylamine / methanol / 0.83 h / 20 - 65 °C

11.1: triethylamine / dichloromethane / 1 h / 20 °C

With ammonium hydroxide; ethanol; cyclohexa-1,4-diene; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile; butan-1-ol;

Reference yield:

: 1379541-17-9
C₁₈H₂₉N₇O₂

: 1943-67-5
4-(t-butyl)phenyl isocyanate

: 1379541-15-7
1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1208987-31-8
benzyl((3aS,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

: 1379541-15-7
1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

4: cyclohexa-1,4-diene; ethanol / palladium 10% on activated carbon / 2 h / 85 °C / Reflux

5: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

6: acetic acid / 3.25 h / Reflux

7: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

8: methylamine / methanol / 0.83 h / 20 - 65 °C

9: triethylamine / dichloromethane / 1 h / 20 °C

With ammonium hydroxide; ethanol; cyclohexa-1,4-diene; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; butan-1-ol;