1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Base Information

Chemical Name:1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
CAS No.:1379540-45-0
Molecular Formula:C₂₆H₃₈N₈O₃
Molecular Weight:510.64
Hs Code.:

Synonyms:1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

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Chemical Property of 1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

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Technology Process of 1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

There total 11 articles about 1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1379541-15-7
1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

: 1379540-45-0
1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: With water; trifluoroacetic acid; at 20 ℃; for 1.5h; Cooling with ice;

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1379540-45-0
1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

1.2: pH 7

2.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

6.1: cyclohexa-1,4-diene; ethanol / palladium 10% on activated carbon / 2 h / 85 °C / Reflux

7.1: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

8.1: acetic acid / 3.25 h / Reflux

9.1: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

10.1: methylamine / methanol / 0.83 h / 20 - 65 °C

11.1: triethylamine / dichloromethane / 1 h / 20 °C

12.1: trifluoroacetic acid; water / 1.5 h / 20 °C / Cooling with ice

With ammonium hydroxide; ethanol; cyclohexa-1,4-diene; water; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile; butan-1-ol;

Reference yield:

: 1208987-31-8
benzyl((3aS,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate

: 1379540-45-0
1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

4: cyclohexa-1,4-diene; ethanol / palladium 10% on activated carbon / 2 h / 85 °C / Reflux

5: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

6: acetic acid / 3.25 h / Reflux

7: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

8: methylamine / methanol / 0.83 h / 20 - 65 °C

9: triethylamine / dichloromethane / 1 h / 20 °C

10: trifluoroacetic acid; water / 1.5 h / 20 °C / Cooling with ice

With ammonium hydroxide; ethanol; cyclohexa-1,4-diene; water; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; butan-1-ol;