(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Chemical Name:(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate
CAS No.:1430112-88-1
Molecular Formula:C₃₆H₃₆ClFN₈O₅
Molecular Weight:715.184
Hs Code.:

(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Synonyms:(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Chemical Property of (E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Technology Process of (E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

There total 8 articles about (E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1094107-98-8
(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

: 1430115-58-4
1-(3,4-dihydroisoquinolin-5-yl)-4-methylpiperazin-2-one

: 1224444-35-2
tert-butyl 4-isocyanobenzoate

: 1430112-88-1
(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: In methanol; at 55 ℃; for 72h; Sealed tube;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: 34770-60-0
4-methyl-2-oxo-piperazine

: 1430112-88-1
(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,10-Phenanthroline; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 24 h / 130 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / ethanol / 2844.39 Torr

3: manganese(IV) oxide / dichloromethane; dimethyl sulfoxide / 24 h / 20 °C

4: methanol / 72 h / 55 °C / Sealed tube

With manganese(IV) oxide; platinum(IV) oxide; copper(l) iodide; 1,10-Phenanthroline; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1: |Ullmann Condensation / 4: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: 1598386-32-3
1-(isoquinolin-5-yl)-4-methylpiperazin-2-one

: 1430112-88-1
(E)-tert-butyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / ethanol / 2844.39 Torr

2: manganese(IV) oxide / dichloromethane; dimethyl sulfoxide / 24 h / 20 °C

3: methanol / 72 h / 55 °C / Sealed tube

With manganese(IV) oxide; platinum(IV) oxide; hydrogen; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; 3: |Ugi Condensation;
DOI:10.1021/acs.jmedchem.7b01171