(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

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Chemical Name:(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester
CAS No.:1094107-98-8
Molecular Formula:C₁₄H₉ClFN₅O₄
Molecular Weight:365.708
Hs Code.:

Synonyms:(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

Suppliers and Price of (E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

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Technology Process of (E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

There total 1 articles about (E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1094106-58-7
trans-3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acrylic acid

: 1094107-98-8
(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 39.0%

: 1094107-98-8
(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

: 1430217-39-2
(S)-methyl 4-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate

: 1430216-03-7
(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; for 1h; Cooling with ice;
DOI:10.1021/acs.jmedchem.7b01171