(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

Base Information

Chemical Name:(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide
CAS No.:1603835-90-0
Molecular Formula:C₃₀H₄₄N₅O₅PSi
Molecular Weight:613.769
Hs Code.:

Synonyms:(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

Chemical Property:

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Technology Process of (S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

There total 7 articles about (S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3095-95-2
diethylphosphonoacetic acid

: C₂₄H₃₃N₅OSi

: 1603835-90-0
(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 9h;
DOI:10.1002/ejoc.201400140

Reference yield:

: 1603835-87-5
(S)-4-amino-5-azido-O-tert-butyldiphenylsilyl-1-pentanol

: 1603835-90-0
(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 9 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201400140

Reference yield:

: 330680-83-6
methyl (4S)-5-azido-4-[(tert-butoxycarbonyl)amino]pentanoate

: 1603835-90-0
(S)-N-(1-azidomethyl-4-O-tert-butyldiphenylsilyloxybutyl)-N-2-cyanoethyl diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / ethanol; tetrahydrofuran / 12.5 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 8 h / 0 - 20 °C

4: ethanol / 24 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 9 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; lithium borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201400140