1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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Chemical Name:1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
CAS No.:1069136-84-0
Molecular Formula:C₂₆H₂₇Cl₂N₃O₃
Molecular Weight:500.425
Hs Code.:

Synonyms:1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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Chemical Property of 1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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Technology Process of 1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

There total 11 articles about 1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1069136-83-9
1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

: 1069136-84-0
1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 503842-32-8
[1,1']bipiperidinyl-2,4-dione

: 1069136-84-0
1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 1 h / Heating / reflux

4.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

5.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 80 °C

6.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 20 °C

7.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; palladium diacetate; In tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 503842-30-6
N-(2-methoxycarbonylethyl)-N-piperidin-1-yl-malonamic acid ethyl ester

: 1069136-84-0
1-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-(4-methoxyphenyl)-5-piperidin-1-yl-1.5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

2.1: acetic acid / water / 1 h / Heating / reflux

3.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 0 - 20 °C

5.1: toluene-4-sulfonic acid / toluene / 1 h / Heating / reflux

6.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

7.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 80 °C

8.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 20 °C

9.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; sodium hydride; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; palladium diacetate; In tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;