1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

Base Information

Chemical Name:1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde
CAS No.:1069136-83-9
Molecular Formula:C₂₆H₂₅Cl₂N₃O₃
Molecular Weight:498.409
Hs Code.:

Synonyms:1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

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Chemical Property of 1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

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Technology Process of 1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

There total 10 articles about 1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1069136-82-8
ethyl 3-[1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

: 1069136-83-9
1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

Guidance literature:: With sodium periodate; osmium(VIII) oxide; water; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃;

Reference yield:

: 503842-32-8
[1,1']bipiperidinyl-2,4-dione

: 1069136-83-9
1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 1 h / Heating / reflux

4.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

5.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 80 °C

6.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 20 °C

With sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; palladium diacetate; In tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 503842-30-6
N-(2-methoxycarbonylethyl)-N-piperidin-1-yl-malonamic acid ethyl ester

: 1069136-83-9
1-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

2.1: acetic acid / water / 1 h / Heating / reflux

3.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 0 - 20 °C

5.1: toluene-4-sulfonic acid / toluene / 1 h / Heating / reflux

6.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

7.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 80 °C

8.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 20 °C

With sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; sodium hydride; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; palladium diacetate; In tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;