(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

Base Information

Chemical Name:(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane
CAS No.:204845-24-9
Molecular Formula:C₂₈H₃₇NO₆
Molecular Weight:483.605
Hs Code.:

Synonyms:(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

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Chemical Property of (4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

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Technology Process of (4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

There total 1 articles about (4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62563-07-9
2-(3-bromopropyl)-1,3-dioxolane

: (4R)-N-(2,4,6-trimethoxybenzyl)-2-(1-propynyl)-4-phenyl-1,3-oxazolidine

: 204845-24-9
(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

Guidance literature:: With magnesium; Yield given. Multistep reaction; 1.) THF, 2.) THF, 0 deg C, 2 d;
DOI:10.1021/jo971127i

Reference yield: 74.0%

: 204845-24-9
(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

: 204845-27-2
(2R,9S)-9-(1-propynyl)-2-phenyl-1-aza-4-oxabicyclo[4.3.0]nonane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 72h; Ambient temperature;
DOI:10.1021/jo971127i

Reference yield:

: 204845-24-9
(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

: 204845-28-3
(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / trifluoroacetic acid / CH₂Cl₂ / 72 h / Ambient temperature

2: 92 percent / tetrahydrofuran; diethyl ether / 48 h / 0 °C

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo971127i