(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

Base Information

Chemical Name:(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine
CAS No.:204845-28-3
Molecular Formula:C₁₇H₂₃NO
Molecular Weight:257.376
Hs Code.:

Synonyms:(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

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Technology Process of (2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

There total 3 articles about (2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 75-16-1
methylmagnesium bromide

: 204845-27-2
(2R,9S)-9-(1-propynyl)-2-phenyl-1-aza-4-oxabicyclo[4.3.0]nonane

: 204845-28-3
(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 48h;
DOI:10.1021/jo971127i

Reference yield:

: 204845-24-9
(4S,1'R)-2-{4-[N-(2,4,6-trimethoxybenzyl)-N-(2'-hydroxy-1'-phenylethyl)amino]heptyn-5-yl}-1,3-dioxolane

: 204845-28-3
(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / trifluoroacetic acid / CH₂Cl₂ / 72 h / Ambient temperature

2: 92 percent / tetrahydrofuran; diethyl ether / 48 h / 0 °C

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo971127i

Reference yield:

: (4R)-N-(2,4,6-trimethoxybenzyl)-2-(1-propynyl)-4-phenyl-1,3-oxazolidine

: 204845-28-3
(2S,6S,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-(1-propynyl)-6-methylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) magnesium / 1.) THF, 2.) THF, 0 deg C, 2 d

2: 74 percent / trifluoroacetic acid / CH₂Cl₂ / 72 h / Ambient temperature

3: 92 percent / tetrahydrofuran; diethyl ether / 48 h / 0 °C

With magnesium; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo971127i