4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

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Chemical Name:4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide
CAS No.:1401803-61-9
Molecular Formula:C₂₁H₂₁ClN₂O₃S
Molecular Weight:416.928
Hs Code.:

Synonyms:4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

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Chemical Property of 4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

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Technology Process of 4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

There total 3 articles about 4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1401803-67-5
5-(4-chlorophenyl)-1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,2,4-trimethyl-1H-pyrrole-3-carboxamide

: 925-90-6
ethylmagnesium bromide

: 1401803-61-9
4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

Guidance literature:: 5-(4-chlorophenyl)-1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,2,4-trimethyl-1H-pyrrole-3-carboxamide; ethylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 1h; Reflux;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 162758-34-1
ethyl [2-acetyl-4-(4-chlorophenyl)-3-methyl-4-oxo]butyrate

: 1401803-61-9
4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 17 h / 95 °C

2.1: sodium hydroxide; water / ethanol / 3 h / Reflux

2.2: pH <= 7

3.1: oxalyl dichloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 1 h / 0 °C / Reflux

With oxalyl dichloride; water; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 5.1: Grignard Reaction;

Reference yield:

: 1401803-66-4
5-(4-chlorophenyl)-2,4-dimethyl-1-(4-sulfamoylphenyl)-1H-pyrrole-3-carboxylic acid

: 1401803-61-9
4-(2-(4-chlorophenyl)-3,5-dimethyl-4-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 1 h / 0 °C / Reflux

With oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane; 3: Grignard Reaction;