methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

Base Information

Chemical Name:methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate
CAS No.:1240422-97-2
Molecular Formula:C₂₅H₂₁ClF₃NO₄S
Molecular Weight:523.96
Hs Code.:

Synonyms:methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

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Technology Process of methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

There total 1 articles about methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1240422-95-0
methyl (R)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)-2-(phenylselanyl)butanoate

: 1240422-97-2
methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

Guidance literature:: With dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; ethyl acetate; at 0 - 21 ℃;
DOI:10.1002/jlcr.1719

Reference yield:

: 1240422-97-2
methyl (R,E)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)but-2-enoate

: 1240497-62-4
methyl (R)-[2,3,4-⁽³⁾H]-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)butanoate

Guidance literature:: With Wilkinson's catalyst; tritium; In N,N-dimethyl-formamide; toluene; at 21 ℃; for 17h; under 1249.62 Torr;
DOI:10.1002/jlcr.1719