{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

Base Information

Chemical Name:{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid
CAS No.:1192322-60-3
Molecular Formula:C₃₀H₃₅NO₆
Molecular Weight:505.611
Hs Code.:

Synonyms:{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

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Chemical Property of {4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

Chemical Property:

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Technology Process of {4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

There total 6 articles about {4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1192322-58-9
(4-[3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)adamantan-1-yl]phenoxy)acetic acid ethyl ester

: 1192322-60-3
{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2009.07.127

Reference yield:

: 828-51-3
1-Adamantanecarboxylic acid

: 1192322-60-3
{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride; bromine / dichloromethane / 49 h / -5 - 20 °C / Inert atmosphere

2: aluminum (III) chloride / 24 h / -10 - 20 °C

3: boron tribromide / dichloromethane / -10 - 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

5: potassium carbonate / N,N-dimethyl-formamide

6: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

With aluminum (III) chloride; water; bromine; boron tribromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₂₈H₃₃NO₄

: 1192322-60-3
{4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-adamantan-1-yl]-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;