10.1007/BF00766246
The research investigates the psychotropic properties and acute toxicity of N-acyl derivatives of D,L-aspartic acid, as well as their impact on the binding of 3H-glutamate to rat brain membranes. The purpose of the study was to enhance the blood-brain barrier permeability and psychoactivity of aspartic acid by synthesizing its N-acyl derivatives, which are less polar and more lipophilic. The researchers synthesized derivatives with various R groups, including butyric, benzoic, and adamantane carboxylic acids, and evaluated their effects on animal behavior, antidepressant activity, antiamnestic action, and acute toxicity. The conclusions drawn from the study indicated that the introduction of an N-acyl group into the aspartic acid molecule significantly altered its psychotropic properties, with compounds II-IV showing psychostimulant and antidepressant effects at low to moderate doses.
10.1016/j.tetlet.2009.02.090
The study investigates the reactions of various carboxylic acids with xenon difluoride (XeF2) in different reaction environments, specifically in CH2Cl2/Pyrex and CH2Cl2/PTFE. The researchers found that Pyrex acts as an effective heterogeneous catalyst, promoting electrophilic reactions that lead to rearrangement, cyclisation, and cationic products. In contrast, reactions in PTFE primarily result in fluorodecarboxylation, likely via a single electron transfer (SET) mechanism. The study examines six structurally diverse carboxylic acids and shows that the products vary significantly depending on the reaction environment. For instance, in Pyrex, the reaction of 1-adamantanecarboxylic acid with XeF2 yields 1-adamantanol, while in PTFE, it produces 1-fluoroadamantane. The study highlights the profound influence of the reaction vessel material on the mechanism and products of these reactions, providing insights into the formation of intermediate fluoroxenon esters and their subsequent transformations.
Xi
