N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

Base Information

Chemical Name:N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide
CAS No.:1017294-00-6
Molecular Formula:C₃₅H₃₆F₅N₃O₂
Molecular Weight:625.682
Hs Code.:

Synonyms:N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

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Chemical Property of N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

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Technology Process of N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

There total 11 articles about N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 676533-86-1
N-(tert-butyl)-2-methyl-6-(trifluoromethyl)nicotinamide

: 1017294-02-8
(R)-2-dibenzylamino-3-(2,5-difluoro-phenyl)-propionaldehyde

: 1017294-00-6
N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

Guidance literature:: N-(tert-butyl)-2-methyl-6-(trifluoromethyl)nicotinamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 65 ℃; for 1h;

With lithium diisopropyl amide; In tetrahydrofuran; hexane; mineral oil; at -20 ℃; for 1h;

(R)-2-dibenzylamino-3-(2,5-difluoro-phenyl)-propionaldehyde; In tetrahydrofuran; hexane; mineral oil; at -20 ℃; for 1h; stereoselective reaction;
DOI:10.1021/op700235c

Reference yield:

: 1017294-02-8
(R)-2-dibenzylamino-3-(2,5-difluoro-phenyl)-propionaldehyde

: 1017294-00-6
N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

Guidance literature:: N-(tert-butyl)-2-methyl-6-(trifluoromethyl)nicotinamide; With n-butyllithium; 1,4-diaminobutane; diisopropylamine; In tetrahydrofuran; at -78 - -58 ℃; for 2.16667h;

(R)-2-dibenzylamino-3-(2,5-difluoro-phenyl)-propionaldehyde; In tetrahydrofuran; at -78 - -40 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran; pH=9;

Reference yield:

: 923564-34-5
2-dibenzylamino-3-(2,5-difluoro-phenyl)-propan-1-ol

: 1017294-00-6
N-tert-butyl-2-[3-dibenzylamino-4-(2,5-difluoro-phenyl)-2-hydroxy-butyl]-6-trifluoromethyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 0.5 h / -9 - 10 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 65 °C

2.2: 1 h / -20 °C

2.3: 1 h / -20 °C

With sulfur trioxide pyridine complex; sodium hydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1021/op700235c