Technology Process of 2-dibenzylamino-3-(2,5-difluoro-phenyl)-propan-1-ol
There total 8 articles about 2-dibenzylamino-3-(2,5-difluoro-phenyl)-propan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
2-methyltetrahydrofuran;
at -10 - 0 ℃;
for 7.5h;
DOI:10.1021/op700235c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / methanol / 24 h / 60 - 65 °C
2: potassium carbonate / acetonitrile; water / 78 °C
3: lithium aluminium tetrahydride / 2-methyltetrahydrofuran / 7.5 h / -10 - 0 °C
With
lithium aluminium tetrahydride; sulfuric acid; potassium carbonate;
In
2-methyltetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/op700235c
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetic anhydride; sodium acetate
2: sodium methylate
3: hydrogen; palladium on activated charcoal / methanol / pH 7.5
4: Protease from Bacillus sp / pH 7.5
5: sulfuric acid / methanol / 24 h / 60 - 65 °C
6: potassium carbonate / acetonitrile; water / 78 °C
7: lithium aluminium tetrahydride / 2-methyltetrahydrofuran / 7.5 h / -10 - 0 °C
With
lithium aluminium tetrahydride; sulfuric acid; palladium on activated charcoal; hydrogen; sodium methylate; sodium acetate; acetic anhydride; potassium carbonate;
In
2-methyltetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/op700235c
