N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide

Base Information

• Chemical Name: N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide
• CAS No.: 198839-50-8
• Molecular Formula: C₁₆H₁₃ClN₂O₄S
• Molecular Weight: 364.809
• Mol file: 198839-50-8.mol

Synonyms:N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide

Chemical Property of N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide

There total 3 articles about N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(5-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (198839-44-0) + propargyl bromide (106-96-7) → N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide (198839-50-8)

Guidance literature:

With benzyltriethylammonium bromide; potassium carbonate; In acetone; at 40 ℃; for 48h;

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide (198839-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 50percent aq. NaOH / benzene / Heating

2: 56 percent / K₂CO₃, PhCH₂(Et)3N+Br- / methanol / 1 h / Heating

3: 96 percent / K₂CO₃, PhCH₂(Et)3N+Br- / acetone / 48 h / 40 °C

With sodium hydroxide; benzyltriethylammonium bromide; potassium carbonate; In methanol; acetone; benzene;

Reference yield:

N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride (198839-43-9) → N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide (198839-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / K₂CO₃, PhCH₂(Et)3N+Br- / methanol / 1 h / Heating

2: 96 percent / K₂CO₃, PhCH₂(Et)3N+Br- / acetone / 48 h / 40 °C

With benzyltriethylammonium bromide; potassium carbonate; In methanol; acetone;

upstream raw materials:

N-(5-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide

propargyl bromide

5-chloro-2-nitroaniline

N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride

Downstream raw materials:

N-(2-Amino-5-chloro-phenyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide

N-(2-Azido-5-chloro-phenyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide