N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride

Base Information

• Chemical Name: N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride
• CAS No.: 198839-43-9
• Molecular Formula: C₂₀H₁₇ClN₂O₆S₂
• Molecular Weight: 480.95
• Mol file: 198839-43-9.mol

Synonyms:N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride

Chemical Property of N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride

There total 1 articles about N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-chloro-2-nitroaniline (1635-61-6) + p-toluenesulfonyl chloride (98-59-9) → N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride (198839-43-9)

Guidance literature:

With sodium hydroxide; In benzene; Heating;

Reference yield: 56.0%

N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride (198839-43-9) → N-(5-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (198839-44-0)

Guidance literature:

With benzyltriethylammonium bromide; potassium carbonate; In methanol; for 1h; Heating;

Reference yield:

N-(5-chloro-2-nitrophenyl)-N-(p-tolylsulfonyl) toluene-p-sulfonyl chloride (198839-43-9) → N-(2-Amino-5-chloro-phenyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide (198839-59-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃, PhCH₂(Et)3N+Br- / methanol / 1 h / Heating

2: 96 percent / K₂CO₃, PhCH₂(Et)3N+Br- / acetone / 48 h / 40 °C

3: 75 percent / 37percent aq.HCl, gl.AcOH, SnCl₂*2H₂O, Zn / 4 h / Ambient temperature

With hydrogenchloride; benzyltriethylammonium bromide; potassium carbonate; acetic acid; tin(ll) chloride; zinc; In methanol; acetone;

upstream raw materials:

5-chloro-2-nitroaniline

p-toluenesulfonyl chloride

Downstream raw materials:

N-(5-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide

N-(2-Amino-5-chloro-phenyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide

N-(5-chloro-2-nitrophenyl)-N-prop-2-ynyl toluene-p-sulfonamide

N-(2-Azido-5-chloro-phenyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide