5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether

Base Information

• Chemical Name: 5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether
• CAS No.: 1174752-17-0
• Molecular Formula: C₂₁H₂₆BrClN₄O₃
• Molecular Weight: 497.819
• Mol file: 1174752-17-0.mol

Synonyms:5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether

Chemical Property of 5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether

There total 1 articles about 5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,5-dibromo-pentane (111-24-0) + 2-[4-(2-chloro-4-nitrophenylazo)-N-ethylphenylamino]ethanol (3180-81-2) → 5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether (1174752-17-0)

Guidance literature:

2-[4-(2-chloro-4-nitrophenylazo)-N-ethylphenylamino]ethanol; With potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; at 20 ℃; for 1h;

1,5-dibromo-pentane; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1002/ejoc.200801302

Reference yield: 87.0%

5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether (1174752-17-0) + diethyl malonate (105-53-3) → diethyl 2-{5'-[2''-(N-ethyl-N-{4'''-[(2''''-chloro-4''''-nitrophenyl)azo]phenyl}amino)ethoxy]pentyl}malonate (1174752-18-1)

Guidance literature:

5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

diethyl malonate; In tetrahydrofuran; for 20h; Reflux;

DOI:10.1002/ejoc.200801302

Reference yield: 43.0%

5-bromopentyl 2-(N-ethyl-N-{4′-[(2″-chloro-4″-nitrophenyl)-phazo]phenyl}amino)ethyl ether (1174752-17-0) + 5′-amino-5′-deoxy-2′,3′-O-isopropylideneuridine (68691-77-0) → 1-[6-[[5-[2-[4-[(E)-(2-chloro-4-nitro-phenyl)azo]-N-ethyl-anilino]ethoxy]pentylamino]methyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4-dione

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1039/c8ob01606b

upstream raw materials:

1,5-dibromo-pentane

2-[4-(2-chloro-4-nitrophenylazo)-N-ethylphenylamino]ethanol

Downstream raw materials:

diethyl 2-{5'-[2''-(N-ethyl-N-{4'''-[(2''''-chloro-4''''-nitrophenyl)azo]phenyl}amino)ethoxy]pentyl}malonate