3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1027582-60-0
Molecular Formula:C₃₁H₃₆BrN₃O₅
Molecular Weight:610.548
Hs Code.:

Synonyms:3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

There total 10 articles about 3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1027582-60-0
3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaNO₂ / acetic acid / 4 h / Ambient temperature

2: H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / ethanol

4: K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; acetyl chloride; sodium nitrite; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: ethyl 4-methyl-2-nitro-3-oxopentanoate

: 1027582-60-0
3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: Et₃N / ethanol

3: K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; acetyl chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 18441-43-5
5-methylbenzofuran

: 1027582-60-0
3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, TMEDA, 2.) triisopropyl borate, 3.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 100 percent / Br₂ / CCl₄ / 0.67 h / 0 - 5 °C

3: 92 percent / aq. NaOH / methanol / 3 h / Heating

4: 18 percent / diphenylphosphorazidate, Et₃N / dioxane / 20 h / Heating

5: 97 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

6: K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Perbenzoic acid; Triisopropyl borate; N,N,N,N,-tetramethylethylenediamine; diphenyl phosphoryl azide; bromine; sodium carbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016