3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1026340-43-1
Molecular Formula:C₂₆H₂₈BrN₃O₃
Molecular Weight:510.431
Hs Code.:

Synonyms:3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

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Chemical Property of 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

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Technology Process of 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

There total 12 articles about 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1026340-43-1
3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂ / acetic acid / 4 h / Ambient temperature

2: H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / ethanol

4: K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

5: trifluoroacetic acid / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; acetyl chloride; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: ethyl 4-methyl-2-nitro-3-oxopentanoate

: 1026340-43-1
3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: Et₃N / ethanol

3: K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

4: trifluoroacetic acid / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; acetyl chloride; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016