(E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine

Base Information

• Chemical Name: (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine
• CAS No.: 1596271-46-3
• Molecular Formula: C₃₁H₂₅Cl₄N₅O
• Molecular Weight: 625.384
• Mol file: 1596271-46-3.mol

Synonyms:(E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine

Chemical Property of (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine

There total 5 articles about (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(7-chloroquinolin-4-yl)propane-1,3-diamine (7597-14-0) + 1-(3-chlorophenyl)-3-(2-(2,5-dichlorophenoxy)phenyl)thiourea (1596271-11-2) → (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine (1596271-46-3)

Guidance literature:

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

2,5-dichlorophenol (583-78-8) → (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine (1596271-46-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: iron; acetic acid / 0.33 h / 90 °C

3: N,N-dimethyl-formamide / 20 °C

4: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With iron; potassium carbonate; acetic acid; triethylamine; mercury dichloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)propyl)-3-(2-(2,5-dichlorophenoxy)phenyl)guanidine (1596271-46-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: iron; acetic acid / 0.33 h / 90 °C

3: N,N-dimethyl-formamide / 20 °C

4: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With iron; potassium carbonate; acetic acid; triethylamine; mercury dichloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.02.044

upstream raw materials:

N-(7-chloroquinolin-4-yl)propane-1,3-diamine

1-(3-chlorophenyl)-3-(2-(2,5-dichlorophenoxy)phenyl)thiourea

2,5-dichlorophenol

ortho-nitrofluorobenzene