7597-14-0Relevant articles and documents
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights
Baartzes,Stringer,Seldon,Warner,Taylor,Wittlin,Chibale,Smith
, p. 121 - 133 (2019)
Phenyl- and bioisosteric ferrocenyl-derived aminoquinoline-benzimidazole hybrid compounds were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human mal
SUBSTITUTED 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE ANALOGS AS MODULATORS OF MELANOMA-ASSOCIATED ANTIGEN 11 UBIQUITIN LIGASE
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Paragraph 0297, (2022/01/24)
Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. These proteins assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets, including key tumor suppressors. However, the development of MAGE-directed therapeutics heretofore has been extremely limited. In one aspect, the disclosure relates to compounds and peptides useful as inhibitors of MAGE-A11:substrate interaction, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disorder associated with a MAGE-A11 dysfunction, e.g., a cancer, using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
4-aminosalicylic acid-based hybrid compounds: Synthesis and in vitro antiplasmodial evaluation
Nqoro, Xhamla,Jama, Siphesihle,Morifi, Eric,Aderibigbe, Blessing Atim
, p. 284 - 298 (2021/04/21)
Background: Malaria is a deadly and infectious disease responsible for millions of death worldwide, mostly in the African region. The malaria parasite has developed resistance to the currently used antimalarial drugs, and it has urged researchers to devel
Synthesis and Antimicrobial Activity of Some Novel 7-Chloro-4-aminoquinoline Derivatives
Fatima, Gul Naz,Paliwal, Sarvesh K.,Saraf, Shailendra K.
, p. 285 - 293 (2021/03/20)
Abstract: A number of novel 7-chloro-4-aminoquinoline derivatives have been efficiently synthesized by nucleophilic aromatic substitution reaction of 4,7-dichloroquinoline with α,ω-diaminoalkanes of variable carbon-chain length. Treatment of the intermedi