Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester
CAS No.:191792-44-6
Molecular Formula:C₂₅H₃₆O₆SSi
Molecular Weight:492.709
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

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Chemical Property of Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

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Technology Process of Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

There total 11 articles about Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 191792-43-5
Toluene-4-sulfonic acid (2S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

: 191792-44-6
Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 50 ℃; for 18h;
DOI:10.1016/S0957-4166(97)00136-5

Reference yield:

: 87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2
D-Xylose

: 191792-44-6
Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 36percent aq. HCl / 0.5 h / Ambient temperature

2: 85 percent / TsCl, pyridine / -15 °C / 1.) -15 deg C, 1.5 h, 2.) RT, 2 d

3: 82 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 3 d

4: 80 percent / pyridine / 72 h / Ambient temperature

5: 85 percent / aq. HgCl₂, HgO / acetonitrile / 1 h / Ambient temperature

6: 95 percent / 10 M BH₃*Me₂S / diethyl ether / 2 h / Ambient temperature

7: 85 percent / NaH / tetrahydrofuran / 18 h / 50 °C

With pyridine; 1H-imidazole; hydrogenchloride; dimethylsulfide borane complex; sodium hydride; p-toluenesulfonyl chloride; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0957-4166(97)00136-5

Reference yield:

: 29325-30-2
diisobutyl 2,5-anhydro-D-xylofuranose dithioacetal

: 191792-44-6
Toluene-4-sulfonic acid (2S,3R,4R)-2-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 3 d

2: 80 percent / pyridine / 72 h / Ambient temperature

3: 85 percent / aq. HgCl₂, HgO / acetonitrile / 1 h / Ambient temperature

4: 95 percent / 10 M BH₃*Me₂S / diethyl ether / 2 h / Ambient temperature

5: 85 percent / NaH / tetrahydrofuran / 18 h / 50 °C

With pyridine; 1H-imidazole; dimethylsulfide borane complex; sodium hydride; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0957-4166(97)00136-5