5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline

Base Information

• Chemical Name: 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline
• CAS No.: 1256496-96-4
• Molecular Formula: C₂₆H₂₃ClN₂O₅S
• Molecular Weight: 510.998
• Mol file: 1256496-96-4.mol

Synonyms:5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline

Chemical Property of 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline

There total 7 articles about 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C25H21ClN2O3 (1256496-95-3) + methanesulfonyl chloride (124-63-0) → 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline (1256496-96-4)

Guidance literature:

With triethylamine; In dichloromethane; for 4h;

DOI:10.3390/molecules15117971

Reference yield:

C10H9N3O3 (1256496-85-1) → 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline (1256496-96-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / Reflux

2: sodium hydroxide / methanol / 1 h / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

4: triethylamine / dichloromethane / 4 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules15117971

Reference yield:

5-hydroxyindole-2-carboxylic acid (21598-06-1) → 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-methylsulfonyloxy-1H-indol-2-yl)carbonyl]indoline (1256496-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

2: triethylamine / dichloromethane / 4 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules15117971

upstream raw materials:

C₂₅H₂₁ClN₂O₃

methanesulfonyl chloride

C₁₀H₉N₃O₃

5-hydroxyindole-2-carboxylic acid