2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

Base Information

Chemical Name:2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide
CAS No.:1265635-34-4
Molecular Formula:C₂₇H₂₂F₂N₄O₅S
Molecular Weight:552.558
Hs Code.:

Synonyms:2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

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Chemical Property of 2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

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Technology Process of 2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

There total 4 articles about 2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1265635-29-7
5-(4-amino-2-fluorophenoxy)-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

: 1265635-34-4
2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 1265637-60-2
tert-butyl 4-chloro-3-((4-methoxybenzylamino)methyl) pyridin-2-ylcarbamate

: 1265635-34-4
2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: acetonitrile / 1 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide

4: pyridine / 20 °C

With pyridine; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 868736-42-9
tert-butyl N-(4-chloro-3-formylpyridin-2-yl)carbamate

: 1265635-34-4
2-fluoro-N-(3-fluoro-4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]oxy}phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: acetonitrile / 1 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide

5: pyridine / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;