(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Base Information

Chemical Name:(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide
CAS No.:145064-00-2
Molecular Formula:C₃₄H₄₅NO₂Si
Molecular Weight:527.822
Hs Code.:

Synonyms:(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Suppliers and Price of (2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Chemical Property:

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Technology Process of (2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

There total 9 articles about (2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 145064-01-3
(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropenyl-7-methyl-4-octanolide

: 145064-15-9
(2S,3R,4S,5S)-5-amino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

: 145064-00-2
(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 48h;
DOI:10.1055/s-1992-26247

Reference yield:

: 111060-65-2
(S)-2-(dibenzylamino)-4-methylpentanal

: 145064-00-2
(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Guidance literature:: Multi-step reaction with 6 steps

2: 2.) MeSO₃H / 1.) Hg(OAc)2 / 1.) MeOH, r.t., 1 h, 2.) r.t., 14 h

3: 81 percent / 3-chloroperoxybenzoic acid (MCPBA), MeSO₃H / CH₂Cl₂ / 24 h / Ambient temperature

5: 91 percent / PCl₅ / CH₂Cl₂ / 3 h / 0 °C

6: 53 percent / H₂ / 10percent Pd/C / ethyl acetate / 24 h

With methanesulfonic acid; phosphorus pentachloride; hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; mercury(II) diacetate; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1992-26247

Reference yield:

: 136320-55-3
3-(dimethylphenylsilyl)-2-propynyl N,N-diisopropylcarbamate

: 145064-00-2
(2S,3R,4S,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2-isopropyl-7-methyl-4-octanolide

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / H₂, ethylenediamine / P-2 Ni / ethanol / Ambient temperature

3: 2.) MeSO₃H / 1.) Hg(OAc)2 / 1.) MeOH, r.t., 1 h, 2.) r.t., 14 h

4: 81 percent / 3-chloroperoxybenzoic acid (MCPBA), MeSO₃H / CH₂Cl₂ / 24 h / Ambient temperature

6: 91 percent / PCl₅ / CH₂Cl₂ / 3 h / 0 °C

7: 53 percent / H₂ / 10percent Pd/C / ethyl acetate / 24 h

With methanesulfonic acid; phosphorus pentachloride; hydrogen; ethylenediamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; mercury(II) diacetate; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1055/s-1992-26247