1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Base Information

Chemical Name:1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester
CAS No.:151979-05-4
Molecular Formula:C₂₃H₂₃N₃O₅
Molecular Weight:421.453
Hs Code.:

Synonyms:1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Suppliers and Price of 1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

There total 10 articles about 1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 201552-68-3
7-[[4-cyanophenyl]methoxy]-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione-4-propanoic acid ethyl ester

: 74-88-4
methyl iodide

: 151979-05-4
1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 151979-05-4
1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 175.8 g / potassium carbonate / dimethylformamide / 2.5 h / 50 °C

2: tetrabutylammonium bromide; potassium permanganate / H₂O; pyridine / 20 °C

3: oxalyl chloride / benzene; dimethylformamide / 20 - 65 °C

4: 800 mg / sodium bicarbonate / tetrahydrofuran; H₂O / 18.3 h / 0 - 20 °C

5: 700 mg / tin(II) chloride dihydrate / ethyl acetate; ethanol / 3.5 h / 70 °C

6: 98 percent / CH₂Cl₂; H₂O / 0.67 h / 0 °C

7: 77 percent / potassium carbonate / dimethylformamide / 2 h / 50 °C

8: 75 percent / cesium carbonate / dimethylformamide / 7 h / 20 °C

With potassium permanganate; oxalyl dichloride; tetrabutylammomium bromide; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; tin(ll) chloride; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; benzene; 1: Etherification / 2: Oxidation / 3: Substitution / 4: Acylation / 5: Reduction / 6: Acylation / 7: Cyclization / 8: Methylation;
DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

: 4244-84-2
ethyl β-alaninate hydrochloride

: 151979-05-4
1-methyl-4-(2-carboxyethyl)-7-(4-cyanobenzyloxy)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 800 mg / sodium bicarbonate / tetrahydrofuran; H₂O / 18.3 h / 0 - 20 °C

2: 700 mg / tin(II) chloride dihydrate / ethyl acetate; ethanol / 3.5 h / 70 °C

3: 98 percent / CH₂Cl₂; H₂O / 0.67 h / 0 °C

4: 77 percent / potassium carbonate / dimethylformamide / 2 h / 50 °C

5: 75 percent / cesium carbonate / dimethylformamide / 7 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; caesium carbonate; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1: Acylation / 2: Reduction / 3: Acylation / 4: Cyclization / 5: Methylation;
DOI:10.1016/S0968-0896(98)80013-8