2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde

Base Information

• Chemical Name: 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde
• CAS No.: 165246-88-8
• Molecular Formula: C₂₇H₃₈O₄Si
• Molecular Weight: 454.682

Synonyms:2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde

Chemical Property of 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde

There total 19 articles about 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propan-1-ol (165246-87-7) → 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde (165246-88-8)

Guidance literature:

With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; -78 deg C to room temperature;

DOI:10.1016/0040-4039(94)88289-4

Reference yield:

(2Ξ,3R)-4,4-Dimethyl-tetrahydro-furan-2,3-diol (103203-99-2,133094-80-1,133094-96-9,134932-06-2,134932-07-3) → 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde (165246-88-8)

Guidance literature:

Multi-step reaction with 13 steps

1: CSA

2: NaH

3: AcOH / H₂O

4: 1.) PivCl, 2.) MsCl, 3.) K₂CO₃ / 1.) pyridine, 2.) pyridine, 3.) MeOH

5: 99 percent / CuI / tetrahydrofuran / -23 deg C to room temperature

6: 1.) OsO₄, NMO, 2.) NaIO₄ / 1.) aq. acetone, t-BuOH, room temperature, 2.) aq. THF, room temperature

7: 67 percent / MsCl, Et₃N, i-Pr₂NEt / CH₂Cl₂ / Heating

8: CH₂Cl₂ / Ambient temperature

9: LiAlH₄ / tetrahydrofuran / Heating

10: 92 percent / imidazole / dimethylformamide / Ambient temperature

11: 90 percent / CSA / CH₂Cl₂ / Ambient temperature

12: 85 percent / H₂ / Pd(OH)2 / tetrahydrofuran / Ambient temperature

13: 92 percent / (COCl)2, Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 deg C to room temperature

With 1H-imidazole; sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; pivaloyl chloride; sodium hydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(94)88289-4

Reference yield:

(R)-4-benzyloxy-3,3-dimethyl-butane-1,2-diol (104708-09-0) → 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde (165246-88-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) PivCl, 2.) MsCl, 3.) K₂CO₃ / 1.) pyridine, 2.) pyridine, 3.) MeOH

2: 99 percent / CuI / tetrahydrofuran / -23 deg C to room temperature

3: 1.) OsO₄, NMO, 2.) NaIO₄ / 1.) aq. acetone, t-BuOH, room temperature, 2.) aq. THF, room temperature

4: 67 percent / MsCl, Et₃N, i-Pr₂NEt / CH₂Cl₂ / Heating

5: CH₂Cl₂ / Ambient temperature

6: LiAlH₄ / tetrahydrofuran / Heating

7: 92 percent / imidazole / dimethylformamide / Ambient temperature

8: 90 percent / CSA / CH₂Cl₂ / Ambient temperature

9: 85 percent / H₂ / Pd(OH)2 / tetrahydrofuran / Ambient temperature

10: 92 percent / (COCl)2, Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 deg C to room temperature

With 1H-imidazole; sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; pivaloyl chloride; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(94)88289-4

upstream raw materials:

2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propan-1-ol

(2Ξ,3R)-4,4-Dimethyl-tetrahydro-furan-2,3-diol

(R)-4-benzyloxy-3,3-dimethyl-butane-1,2-diol

(S)-2-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxirane

Downstream raw materials:

(2R,4S,5R,6S)-5-Benzyloxy-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-4,6-dimethoxy-3,3-dimethyl-tetrahydro-pyran

3-Chloro-benzoic acid (3R,4S,6R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-3-hydroxy-4-methoxy-5,5-dimethyl-tetrahydro-pyran-2-yl ester

(S)-4-((2R,4S,5R,6S)-5-Benzyloxy-4,6-dimethoxy-3,3-dimethyl-tetrahydro-pyran-2-ylmethyl)-[1,3]dioxolan-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 165246-88-8 2-[(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methyl-propionaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send