2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

Base Information

Chemical Name:2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone
CAS No.:320337-75-5
Molecular Formula:C₂₂H₂₅F₂NO₃
Molecular Weight:389.442
Hs Code.:

Synonyms:2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

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Chemical Property of 2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

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Technology Process of 2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

There total 1 articles about 2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 320337-74-4
N-benzyl-2-(tetrahydro-2H-pyran-2-yloxy)-1-ethyl-amine maleate

: 51336-95-9
2-chloro-1-(3,4-difluorophenyl)ethan-1-one

: 320337-75-5
2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

Guidance literature:: N-benzyl-2-(tetrahydro-2H-pyran-2-yloxy)-1-ethyl-amine maleate; With potassium carbonate; In dichloromethane; water;

2-chloro-1-(3,4-difluorophenyl)ethan-1-one; With sodium hydrogencarbonate; In tetrahydrofuran; water; for 3.83333h; Heating / reflux;

Reference yield:

: 320337-75-5
2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone

: 1826-67-1
vinyl magnesium bromide

: 320337-76-6
1-{benzyl[2-(tetrahydropyran-2-yloxy)ethyl]amino}-2-(3,4-difluorophenyl)but-3-en-2-ol

Guidance literature:: 2-{benzyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-amino}-1-(3,4-difluorophenyl)-1-ethanone; vinyl magnesium bromide; In tetrahydrofuran; at 50 - 55 ℃; for 2.5h;

With water; ammonium chloride; In tetrahydrofuran; at 30 ℃; for 0.75h;