5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

Base Information

Chemical Name:5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide
CAS No.:1423036-78-5
Molecular Formula:C₂₂H₁₉Cl₂F₃N₆O₄
Molecular Weight:559.332
Hs Code.:

5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

Synonyms:5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

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Chemical Property of 5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

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Technology Process of 5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

There total 6 articles about 5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 754951-70-7
2-(aminooxy)-N-methylacetamide

: 1423036-79-6
6-chloro-2-[5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-8-methylbenzo[d][1,3]oxazin-4-one

: 1423036-78-5
5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

Guidance literature:: In dimethyl sulfoxide; at 75 ℃; for 4h;

Reference yield:

: 57266-69-0
3-chloropyridine-2-carboxylic acid

: 1423036-78-5
5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 1 h / 110 °C

2.1: triethylamine; magnesium chloride / acetonitrile / 3 h / 10 - 20 °C

2.2: 0 - 25 °C

3.1: 2 h / Reflux

4.1: ethanol / 2 h / Reflux

5.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 100 °C

6.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

6.2: 1 h / 0 °C

6.3: 0 - 25 °C

7.1: dimethyl sulfoxide / 4 h / 75 °C

With thionyl chloride; water; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; magnesium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1423030-56-1
3-(3-chloropyridin-2-yl)-3-oxopropionic acid ethyl ester

: 1423036-78-5
5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (4-chloro-2-methyl-6-methylcarbamoylmethoxycarbamoylphenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / Reflux

2.1: ethanol / 2 h / Reflux

3.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 100 °C

4.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

4.2: 1 h / 0 °C

4.3: 0 - 25 °C

5.1: dimethyl sulfoxide / 4 h / 75 °C

With water; methanesulfonyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; acetonitrile;