(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

Base Information

Chemical Name:(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide
CAS No.:176198-64-4
Molecular Formula:C₂₁H₂₇NO₃
Molecular Weight:341.45
Hs Code.:

Synonyms:(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

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Technology Process of (R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

There total 3 articles about (R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 173054-08-5
<1S(R),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-(tert-butyldimethylsilyloxy)-N-methyl-2-(phenylmethyl)butanamide

: 176198-64-4
(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 0.25h;
DOI:10.1021/jo952032o

Reference yield:

: 14980-86-0,42407-58-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

: 176198-64-4
(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium N,N-diisopropylamide, lithium chloride / 1.) THF, -78 -> 23 deg C, 2.) THF, 5.5 h

2: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / 23 °C

With tetrabutyl ammonium fluoride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo952032o

Reference yield:

: 75-21-8,99932-75-9
oxirane

: 14980-86-0,42407-58-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

: (S)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

: 176198-64-4
(R)-2-Benzyl-4-hydroxy-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-butyramide

Guidance literature:: With lithium chloride; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 -> 23 deg C, 2.) THF, 1 h;
DOI:10.1021/jo952032o