(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

Base Information

Chemical Name:(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one
CAS No.:1416861-33-0
Molecular Formula:C₁₇H₂₃NO₃S
Molecular Weight:321.441
Hs Code.:

Synonyms:(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

Suppliers and Price of (4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

Chemical Property:

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Technology Process of (4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

There total 5 articles about (4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416861-31-8
(4aS,7S,8aS)-tert-butyl 7-methyl-1-(4-methylphenylsulfonyl)-5-oxodecahydroquinoline-6-carboxylate

: 1416861-33-0
(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/ol303257y

Reference yield:

: (4aR,7S,8aS)-7-methyl-5-oxodecahydroquinoline

: 98-59-9
p-toluenesulfonyl chloride

: 1416861-33-0
(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

: (4aRS,7SR,8aSR)-7-methyl-5-oxo-1-(4-methylphenylsulfonyl)decahydroquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/acs.jnatprod.9b00071

Reference yield:

: 1416861-30-7
tert-butyl 7-(4-methylphenylsulfonamido)-3-oxoheptanoate

: 1416861-33-0
(4aS,7S,8aS)-7-methyl-1-(4-methylphenylsulfonyl)octahydroquinolin-5(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: C₃₅H₃₃NOSi; lithium acetate / toluene / 36 h / 0 °C / Inert atmosphere

2: lithium hydroxide / isopropyl alcohol; water / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / 3.25 h / 20 - 80 °C / Inert atmosphere

With C₃₅H₃₃NOSi; lithium acetate; trifluoroacetic acid; lithium hydroxide; In water; isopropyl alcohol; toluene; 1: |Michael Addition;
DOI:10.1039/c4cc01708k