(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

Base Information

Chemical Name:(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline
CAS No.:1416861-35-2
Molecular Formula:C₂₃H₃₀N₂O₂S
Molecular Weight:398.569
Hs Code.:

Synonyms:(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

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Chemical Property of (4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

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Technology Process of (4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

There total 5 articles about (4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4aR,7R,8aS)-7-methyl-1-[(4-methylbenzene)sulfonyl]-5-(pyridin-2-ylmethylidene)decahydroquinoline

: 1416861-35-2
(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

Guidance literature:: With palladium on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol303257y

Reference yield:

: 22353-29-3
4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide

: (4aR,7S,8aS)-7-methyl-1-tosyl-1,2,3,4,4a,7,8,8a-octahydroquinoline

: 1416861-35-2
(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

: (4aR,5S,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

Guidance literature:: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide; (4aR,7S,8aS)-7-methyl-1-tosyl-1,2,3,4,4a,7,8,8a-octahydroquinoline; With iron(III)-acetylacetonate; phenylsilane; In ethanol; at 60 ℃; for 24h; Inert atmosphere;

With triethylamine; In ethanol; at 80 ℃; for 1h; Overall yield = 36 percent; Overall yield = 56 mg; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.9b04459

Reference yield:

: (4aR,7R,8aS)-7-methyl-1-[(4-methylbenzene)sulfonyl]-5-(pyridin-2-ylmethylidene)decahydroquinoline

: 1416861-35-2
(4aR,5R,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

: (4aR,5S,7R,8aS)-7-methyl-1-(4-methylphenylsulfonyl)-5-(pyridin-2-ylmethyl)decahydroquinoline

Guidance literature:: With Wilkinson's catalyst; hydrogen; In dichloromethane; for 24h; diastereoselective reaction;
DOI:10.1021/acs.orglett.5b02581