6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride

Base Information

• Chemical Name: 6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride
• CAS No.: 1006-21-9
• Molecular Formula: C8H9 N O2 . Cl H
• Molecular Weight: 187.626
• European Community (EC) Number: 213-741-1
• DSSTox Substance ID: DTXSID80905620
• Mol file: 1006-21-9.mol

Synonyms:1006-21-9;6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride;1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol hydrochloride;6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride;EINECS 213-741-1;1,3-Dihydro-6-methylfuro(3,4-c)pyridin-7-ol hydrochloride;Pyridoxine Cyclic Ether Impurity Hydrochloride Salt;C8H9NO2.ClH;Pyridoxine HCl Impurity A;SCHEMBL11161014;DTXSID80905620;RTYSWYUCXGLWNW-UHFFFAOYSA-N;BAA00621;BCP27839;MFCD18803544;AKOS037648491;BS-14154;CS-0153481;C71036;EN300-7818744;Z1216824433;6-METHYL-1,3-DIHYDROFURO[3,4-C]PYRIDIN-7-OL HCL;6-METHYL-1H,3H-FURO[3,4-C]PYRIDIN-7-OL HYDROCHLORIDE;6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol--hydrogen chloride (1/1);Pyridoxine Impurity A HCl;1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol Hydrochloride

Chemical Property of 6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride

Chemical Property:

• Vapor Pressure: 1.23E-05mmHg at 25°C
• Melting Point: 239-240 °C (decomp)
• Boiling Point: 358.5°Cat760mmHg
• Flash Point: 170.6°C
• PSA: 42.35000
• Density: g/cm³
• LogP: 1.92780
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 187.0400063
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

PyridoxineCyclicEtherImpurityHydrochlorideSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C2COCC2=C1O.Cl
• Uses: Pyridoxine (P991735) analog. Pyridoxine impurity.

Technology Process of 6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride

There total 4 articles about 6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridoxal hydrochloride (58-56-0) → 6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol; hydrochloride (1006-21-9)

Guidance literature:

With hydrogenchloride; In ethanol; water;

Reference yield:

4-methyloxazole (693-93-6) + 3-methanesulfonyl-2,5-dihydro-furan (41409-84-1) → 6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol; hydrochloride (1006-21-9)

Guidance literature:

at 130 ℃; for 10h;

DOI:10.1002/jlac.197919791104

Reference yield:

water (7732-18-5) + 2-Methyl-3-hydroxy-4,5-bis-(bromomethyl)-pyridine hydrobromide (39984-49-1) → 6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol; hydrochloride (1006-21-9)

Guidance literature:

DOI:10.1021/ja01267a021

upstream raw materials:

4-methyloxazole

3-methanesulfonyl-2,5-dihydro-furan

sulfuric acid

water