4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

Base Information

Chemical Name:4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile
CAS No.:1313055-03-6
Molecular Formula:C₂₅H₂₀FNO₃S
Molecular Weight:433.503
Hs Code.:

Synonyms:4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

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Chemical Property of 4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

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Technology Process of 4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

There total 3 articles about 4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 3290-53-7
2-methyl-1-phenyl-2-propene

: 1313054-92-0
4-[2-(4-fluorophenylsulfonyl)acetyl]benzonitrile

: 1313055-03-6
4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

Guidance literature:: With copper diacetate; manganese(III) triacetate dihydrate; acetic acid; at 50 - 80 ℃; for 0.75h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.04.026

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1313055-03-6
4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; sodium sulfite / water / 0.33 h / 100 °C / Microwave irradiation

1.2: 0.17 h / 100 °C / Microwave irradiation

2.1: copper diacetate; manganese(III) triacetate dihydrate; acetic acid / 0.75 h / 50 - 80 °C / Microwave irradiation

With copper diacetate; manganese(III) triacetate dihydrate; sodium hydrogencarbonate; acetic acid; sodium sulfite; In water;
DOI:10.1016/j.ejmech.2011.04.026

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1313055-03-6
4-[5-benzyl-3-(4-fluorophenylsulfonyl)-5-methyl-4,5-dihydrofuran-2-yl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; sodium sulfite / water / 0.33 h / 100 °C / Microwave irradiation

1.2: 0.17 h / 100 °C / Microwave irradiation

2.1: copper diacetate; manganese(III) triacetate dihydrate; acetic acid / 0.75 h / 50 - 80 °C / Microwave irradiation

With copper diacetate; manganese(III) triacetate dihydrate; sodium hydrogencarbonate; acetic acid; sodium sulfite; In water;
DOI:10.1016/j.ejmech.2011.04.026