(E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester

Base Information

• Chemical Name: (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester
• CAS No.: 129150-70-5
• Molecular Formula: C₂₄H₂₉NO₆
• Molecular Weight: 427.497

Synonyms:(E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester

Chemical Property of (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester

Chemical Property:

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Technology Process of (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester

There total 2 articles about (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dihydroisoferulic acid (1135-15-5) → (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester (129150-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Et₃N, DPPA / 8 h / 80 °C

With diphenyl-phosphinic acid; triethylamine;

DOI:10.1021/jo00311a019

Reference yield:

N-(Boc)-3'-hydroxy-4'-methoxyphenethylamine (31493-49-9) + trans-3-(4-iodophenyl)-2-propenoic acid ethyl ester (161634-73-7) → (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester (129150-70-5)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00311a019

Reference yield: 100.0%

(E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester (129150-70-5) → 3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid methyl ester (129150-72-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 3h; under 2280 Torr;

DOI:10.1021/jo00311a019

upstream raw materials:

N-(Boc)-3'-hydroxy-4'-methoxyphenethylamine

trans-3-(4-iodophenyl)-2-propenoic acid ethyl ester

dihydroisoferulic acid

Downstream raw materials:

3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid methyl ester

3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-hydroxy-phenoxy]-phenyl}-propionic acid

3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-hydroxy-phenoxy]-phenyl}-propionic acid methyl ester

(S)-4-Hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20 hexaene

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