161634-73-7

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 186581-53-3 diazomethane 
• 113641-76-2 (E)-4-iodocinnamic acid 
• 540-37-4 p-aminoiodobenzene 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 1514-50-7 4-iodobenzenediazonium tetrafluoroborate 

Downstream Products

• 129150-70-5 (E)-3-{4-[5-(2-tert-Butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester 
• 129150-69-2 (E)-3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-acrylic acid methyl ester 
• 161634-74-8 (2E)-3-(4-iodophenyl)-prop-2-en-1-ol 
• 161634-85-1 methyl (2R,3S)-2,3-dihydroxy-3-(4-iodophenyl)propionate 
• 1420837-04-2 methyl (2E)-3-(4-ethynylphenyl)prop-2-enoate 
• 1257107-65-5 (R)-3-{4-[3-(1-Naphthalen-1-yl-ethylamino)-propyl]-phenyl}-propionic acid 
• 120363-46-4 3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-methoxy-phenoxy)-phenyl]-propionic acid pentafluorophenyl ester; hydrochloride 
• 120363-39-5 (S)-2-(3-{4-[5-(2-Amino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride 
• 120363-37-3 (S)-2-(3-{4-[5-(2-Amino-ethyl)-2-hydroxy-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride 
• 120363-35-1 (S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride 
• 120363-31-7 3-(4-{5-[2-(2-Amino-acetylamino)-ethyl]-2-methoxy-phenoxy}-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride 
• 120363-38-4 (S)-2-(3-{4-[5-(2-Amino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid; hydrochloride 
• 120363-45-3 3-[4-(5-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-ethyl}-2-methoxy-phenoxy)-phenyl]-propionic acid; hydrochloride 
• 120363-36-2 (S)-2-(3-{4-[5-(2-Amino-ethyl)-2-hydroxy-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid; hydrochloride 

Relevant academic research and scientific papers

Electrochemical Proton Reduction over Nickel Foam for Z-Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes

Selective reduction strategies based on abundant-metal catalysts are very important in the production of chemicals. In this paper, a method for the electrochemical semihydrogenation and semideuteration of alkynes to form Z-alkenes was developed, using a simple nickel foam as catalyst and H3O+ or D3O+ as sources of hydrogen or deuterium. Good yields and excellent stereoselectivities (Z/E up to 20 : 1) were obtained under very mild reaction conditions. The reaction proceeded with terminal and nonterminal alkynes, and also with alkynes containing easily reducible functional groups, such as carbonyl groups, as well as aryl chlorides, bromides, and even iodides. The nickel-foam electrocatalyst could be recycled up to 14 times without any change in its catalytic properties.

Utilization of Synthetic Calcium-Phyllosilicates as Bifunctional Bases in the Matsuda-Heck Reaction

Calcium-phyllosilicates can successfully be used as novel bases in the Matsuda-Heck reaction using methanol as solvent. The new experimental set-up distinguishes itself by higher reactivity and better selectivity compared to other systems.

Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and 'drug-like' structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

Multibond Forming Tandem Reactions of Anilines via Stable Aryl Diazonium Salts: One-Pot Synthesis of 3,4-Dihydroquinolin-2-ones

A fast and effective one-pot tandem process that generates Heck coupled products from readily available anilines via stable aryl diazonium tosylate salts was developed. The mild and simple procedure involves rapid formation of aryl diazonium salts using a polymer-supported nitrite reagent and p-tosic acid, followed by a base-free Heck-Matsuda coupling with acrylates and styrenes. Using 2-nitroanilines as substrates, the one-pot tandem process was extended for the direct synthesis of 3,4-dihydroquinolin-2-ones. In this case, following diazotization and Heck-Matsuda coupling to give methyl cinnamates, addition of hydrogen and reutilization of the palladium catalyst for reduction of the nitro group and hydrogenation of the alkene resulted in efficient formation of 3,4-dihydroquinolin-2-ones. The synthetic utility of this one-pot, four-stage process was demonstrated with the five-pot synthesis of a quinolinone-based sodium ion channel modulator.

SYNTHETIC RETINOIDS (IN CELL MODULATION)

There are described novel compounds of formula I: (I) in which, in which A1, A2, A3, A4, R1 and R2 are each as herein defined, for use in the treatment or alleviation of an RAR mediated condition; and methods related thereto.

CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS

A compound of general formula I their use as calcium receptor-active compounds for the prophylaxis, treatment or amelioration of physiological disorders or diseases associated with disturbances of CaSR activity, such as hyperparathyroidism, pharmaceutical

METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B

The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.

COMPOUNDS HAVING SELECTIVE CYTOCHROME P450RAI-1 OR SELECTIVE CYTOCHROME P450RAI-2 INHIBITORY ACTIVITY AND METHODS OF OBTAINING THE SAME

Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

TYROSINE PHOSPHATASE SCAFOLD SYNTHESIS

Disclosed are 4-(difluoromethylene)phosphonate cinnamic acid derivatives as a molecular scaffold for the preparation of protein tyrosine phosphatase inhibitors. The invention also relates to a process for the combinatorial preparation of protein tyrosine phospatase inhibitors possessing a 4-(difluoromethylene)phosphonate cinnamic acid/ester molecular scaffold

Investigation of the behavior of arenediazonium salts with olefins in BmimPF6

The palladium-catalyzed reactions of olefins with arenediazonium salts in ionic liquids were investigated. For methyl acrylate and methyl acrylonitrile, normal Heck cross-coupling products are obtained in good yields. However, highly selective dimerization products are formed in excellent yields for styrenes. The catalyst system can be recycled.