7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
CAS No.:1186331-98-5
Molecular Formula:C₃₀H₂₈ClN₇O
Molecular Weight:538.052
Hs Code.:

Synonyms:7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

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Chemical Property of 7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

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Technology Process of 7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

There total 2 articles about 7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1186334-40-6
7-(6-bromopyridin-3-yl)-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

: 6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5
(3R)-quinuclidin-3-amine dihydrochloride

: 1186331-98-5
7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 150 ℃; for 1.08333h; Microwave irradiation;

Reference yield:

: 1134598-79-0
4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine

: 1186331-98-5
7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 1 h / 120 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1.08 h / 150 °C / Microwave irradiation

With acetic acid; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;