1134598-79-0

Basic information

• Product Name: 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine
• Synonyms: 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine
• CAS NO: 1134598-79-0
• Molecular Weight: 300.747
• Mol File: 1134598-79-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine(1134598-79-0)
• EPA Substance Registry System: 4-(4-chloro-3-methoxyphenyl)-5-pyridin-4-yl-1H-pyrazol-3-amine(1134598-79-0)

Safety Data

• Hazardous Substances Data: 1134598-79-0(Hazardous Substances Data)

Upstream product

• 1184103-49-8 3-chloro-2-(4-chloro-3-methoxyphenyl)-3-pyridin-4-ylacrylonitrile 
• 13726-21-1 2-(4-chloro-3-methoxyphenyl)acetonitrile 
• 1184103-48-7 2-(4-chloro-3-methoxyphenyl)-3-oxo-3-pyridin-4-ylpropanenitrile 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 1134598-60-9 8-(4-chloro-3-methoxyphenyl)-4-phenyl-7-pyridin-4-ylpyrazolo[5,1-c][1,2,4]triazine 
• 1186334-40-6 7-(6-bromopyridin-3-yl)-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine 
• 1184103-08-9 12-benzyl-3-(4-chloro-3-methoxyphenyl)-8-(phenylsulfonyl)-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta[e]pyrazolo[1,5-a]pyrimidine 
• 1184103-06-7 2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol 
• 1184103-03-4 methyl 3-(4-chloro-3-hydroxyphenyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta-[e]pyrazolo[1,5-a]pyrimidine-8-carboxylate 
• 1184103-00-1 2-chloro-5-[12-methyl-8-(phenylsulfonyl)-2-pyridin-4-yl-7,8,9,10-tetrahydro-61-1-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol 
• 1186331-98-5 7-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]pyridin-3-yl}-3-(4-chloro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine 
• 1134598-81-4 5-(3-amino-5-pyridin-4-yl-1H-pyrazol-4-yl)-2-chlorophenol 

Relevant articles and documents

Discovery of highly potent and selective type I B-Raf kinase inhibitors

A series of pyrazolo[1,5-α]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.

PYRAZOLO[5, 1-C] [1,2,4] TRIAZINES, METHODS FOR PREPARATION AND USE THEREOF

A pyrazolo[5,1-c][1,2,4]triazine compound of formula A: and pharmaceutically acceptable sats thereof. The multiply-substituted pyrazolo[5,1-c][1,2,4]triazine compounds of the invention selectively inhibit B-Raf kinase activity and are useful for treating disorders mediated by B-Raf kinase.

BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.