ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

Base Information

Chemical Name:ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate
CAS No.:1373423-87-0
Molecular Formula:C₃₀H₃₉N₇O₅
Molecular Weight:577.684
Hs Code.:

Synonyms:ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

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Chemical Property of ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

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Technology Process of ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

There total 5 articles about ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 1373423-86-9
ethyl N-[6-{[2-(3-aminophenyl)ethyl]amino}-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

: 1373423-87-0
ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1373423-87-0
ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane

2.1: aminopropyl column / methanol

2.2: 1.17 h / 20 - 160 °C / Inert atmosphere; Sealed vial; Microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 40 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

With hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 10235-65-1
2-(pyridin-2-yl)-4,6-dichloropyrimidine

: 1373423-87-0
ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane

2.1: aminopropyl column / methanol

2.2: 1.17 h / 20 - 160 °C / Inert atmosphere; Sealed vial; Microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 40 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

With hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate;