10235-65-1

Basic information

• Product Name: 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
• Synonyms: Pyrimidine, 4,6-dichloro-2-(2-pyridinyl)-;4,6-Dichloro-2-(pyridin-2-yl);4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
• CAS NO: 10235-65-1
• Molecular Formula: C₉H₅Cl₂N₃
• Molecular Weight: 226.06
• Mol File: 10235-65-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 254.534 °C at 760 mmHg
• Flash Point: 132.361 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.57±0.19(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE(10235-65-1)
• EPA Substance Registry System: 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE(10235-65-1)

Safety Data

• Hazardous Substances Data: 10235-65-1(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-(2-pyridinyl)pyrimidine is a chemical compound with the molecular formula C9H5Cl2N3. It is a pale yellow to brown solid that is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE is a pyrimidine derivative with two chlorine atoms and a pyridinyl group attached to the pyrimidine ring. It is primarily used as an intermediate in the production of various chemicals and can also be used as a research reagent in organic synthesis and chemical analysis. As a chemical compound, 4,6-Dichloro-2-(2-pyridinyl)pyrimidine has potential applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C9H5Cl2N3/c10-7-5-8(11)14-9(13-7)6-3-1-2-4-12-6/h1-5H

Upstream product

• 100-70-9 2-Cyanopyridine 
• 52313-50-5 pyridine-2-carboxamidine 
• 10198-74-0 2-pyridin-2-yl-1H-pyrimidine-4,6-dione 

Downstream Products

• 1014720-73-0 6-chloro-2-(2-pyridin-2-yl)pyrimidin-4-ylamine 
• 67-63-0 isopropyl alcohol 
• 1373423-88-1 ethyl N-[6-({2-[3-(β-alanylamino)phenyl]ethyl}amino)-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate 
• 1373423-87-0 ethyl N-[6-[(2-{3-[(N-{[(1,1-dimethylethyl)oxy]carbonyl}-β-alanyl)amino]phenyl}ethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate 
• 1373423-86-9 ethyl N-[6-{[2-(3-aminophenyl)ethyl]amino}-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate 
• 1373423-17-6 ethyl N-[6-chloro-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate 
• 1172113-85-7 {4-[5-(6-chloro-2-pyridin-2-yl-pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-(4-isopropyl-piperazin-1-yl)-methanone 
• 1172113-88-0 4-chloro-6-[5-(3-methoxy-phenyl)-pyridin-3-yl]-2-pyridin-2-yl-pyrimidine 
• 1373422-53-7 GSK-J1 
• 1373421-99-8 N-[6-[(phenylmethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alanine 
• 1373423-53-0 GSKJ4 
• 1373423-54-1 Ethyl N-[6-[(phenylmethyl)amino]-2-(2-pyridinyl)-4-pyrimidinyl]-β-alaninate 

Relevant articles and documents

Histone demethylase JMJD3 inhibitor, preparation method and application thereof

The invention relates to compound shown as general formula (I), its stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate, ester and crystal. The compound shown as general formula (I) in the invention can inhibit histone demethylase JMJD3, is used for regulating the apparent states of cells and treating a series of histone demethylase JMJD3 mediated diseases and symptoms, which specifically include lung cancer, liver cancer, primary hodgkin lymphoma, some hematologic malignant tumors, inflammation and self-immune diseases, etc.

PYRIMIDINES AS KINASE INHIBITORS

Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmo

Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.