2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

Base Information

Chemical Name:2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid
CAS No.:681246-12-8
Molecular Formula:C₂₆H₃₄N₂O₄S
Molecular Weight:470.633
Hs Code.:

Synonyms:2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

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Chemical Property of 2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

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Technology Process of 2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

There total 10 articles about 2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 681248-15-7
methyl 2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

: 681246-12-8
2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: With pyridine; lithium iodide; at 150 ℃; for 0.583333h; Microwave;

Reference yield:

: 681248-16-8
methyl 2-[(1{2-[5-(diethylamino)pentyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

: 2-[({2-[5-(diethylamino)pentyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

: 681246-12-8
2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: With pyridine; lithium iodide; at 150 ℃; for 0.583333h; Microwave;

Reference yield:

: 947-65-9
methyl 2-hydroxy-1-naphthoate

: 681246-12-8
2-[({2-[(1E)-5-(diethylamino)-1-pentenyl]phenyl}sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / H₂ / Pd/C / methanol; H₂O / 2.5 h / 60 °C / 77572.2 Torr

2: pyridine / CH₂Cl₂ / -20 - 20 °C

3: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

4: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

5: pyridine / 20 °C

6: Pd(PtBu₃)2 / toluene / 1.5 h / 90 °C

7: LiI; pyridine / 0.58 h / 150 °C / microwave irradiation

With pyridine; hydrogenchloride; palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium iodide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; toluene; 3: Buchwald reaction;
DOI:10.1021/jm0601001