(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

Base Information

Chemical Name:(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline
CAS No.:1313392-77-6
Molecular Formula:C₁₇H₃₀N₂O₃Si
Molecular Weight:338.522
Hs Code.:

Synonyms:(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

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Technology Process of (S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

There total 5 articles about (S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 93524-74-4
(S)-3-methyl-2-[(2-nitrophenyl)amino]butan-1-ol

: 1313392-77-6
(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2011.04.049

Reference yield:

: 1313392-68-5
(2S)-3-methyl-2-(2-nitrophenylamino)butyric acid methyl ester

: 1313392-77-6
(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: 1H-imidazole / dichloromethane / 0.5 h / 0 - 20 °C

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.04.049

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1313392-77-6
(S)-N-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-2-nitroaniline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 80 °C

2: thionyl chloride / 0 °C

3: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C

4: 1H-imidazole / dichloromethane / 0.5 h / 0 - 20 °C

With 1H-imidazole; lithium borohydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.04.049