(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

Base Information

Chemical Name:(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide
CAS No.:1620893-80-2
Molecular Formula:C₄₄H₄₇N₃O₁₀
Molecular Weight:777.871
Hs Code.:

Synonyms:(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

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Chemical Property of (2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

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Technology Process of (2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

There total 7 articles about (2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1206617-50-6
2-azido-4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazole

: 10263-19-1,89652-61-9
(E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride

: 1620893-80-2
(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 1206617-46-0
4-iodo-5-(4-methoxybenzyl)-1-methyl-1H-imidazole

: 1620893-80-2
(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

1.2: 12 h / 25 °C / Inert atmosphere

2.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

3.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C

4.2: 1 h / -78 - 25 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; ethylmagnesium bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 1197054-82-2
(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

: 1620893-80-2
(2E)-N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)-N-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

3.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

4.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C

5.2: 1 h / -78 - 25 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With triethylsilane; n-butyllithium; palladium 10% on activated carbon; boron trifluoride diethyl etherate; ethylmagnesium bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016