(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

Base Information

• Chemical Name: (4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol
• CAS No.: 1197054-82-2
• Molecular Formula: C₁₂H₁₃IN₂O₂
• Molecular Weight: 344.152
• Mol file: 1197054-82-2.mol

Synonyms:(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

Chemical Property of (4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

There total 1 articles about (4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxy-benzaldehyde (123-11-5) + 4,5-diiodo-1-methyl-1H-imidazole (37067-96-2) → (4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol (1197054-82-2)

Guidance literature:

4,5-diiodo-1-methyl-1H-imidazole; With ethylmagnesium bromide; In dichloromethane;

4-methoxy-benzaldehyde;

DOI:10.1016/j.tetlet.2009.10.117

Reference yield: 97.0%

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol (1197054-82-2) → 4-iodo-5-(4-methoxybenzyl)-1-methyl-1H-imidazole (1206617-46-0)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; Reflux;

DOI:10.1016/j.tetlet.2009.10.117

Reference yield: 72.0%

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol (1197054-82-2) + methyl iodide (74-88-4) → 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole (1197054-83-3)

Guidance literature:

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 60 ℃; for 2.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1216929

upstream raw materials:

4-methoxy-benzaldehyde

4,5-diiodo-1-methyl-1H-imidazole

Downstream raw materials:

4-iodo-5-(4-methoxybenzyl)-1-methyl-1H-imidazole

4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

C₁₂H₁₃IN₂O₂

C₁₂H₁₃IN₂O₂