(S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide

Base Information

• Chemical Name: (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide
• CAS No.: 777833-33-7
• Molecular Formula: C₂₀H₂₂F₂N₂O₂
• Molecular Weight: 360.404

Synonyms:(S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide

Chemical Property of (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide

Chemical Property:

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Technology Process of (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide

There total 2 articles about (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-[bis(4-fluorophenyl)methoxy]ethyl chloride (50366-31-9) + L-prolinamide (7531-52-4) → (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide (777833-33-7)

Guidance literature:

With potassium carbonate; In toluene; for 24h; Heating;

DOI:10.1021/jm960305h

Reference yield:

4,4'-difluorobenzhydryl alcohol (365-24-2) → (S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide (777833-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / toluene

2: 32 percent / K₂CO₃ / toluene / 24 h / Heating

With sulfuric acid; potassium carbonate; In toluene;

DOI:10.1021/jm960305h

Reference yield: 93.0%

(S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide (777833-33-7) → C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine (183865-99-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm960305h

upstream raw materials:

2-[bis(4-fluorophenyl)methoxy]ethyl chloride

L-prolinamide

4,4'-difluorobenzhydryl alcohol

Downstream raw materials:

C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

N-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-ylmethyl)-3-phenyl-propionamide

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