C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

Base Information

Chemical Name:C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine
CAS No.:183865-99-8
Molecular Formula:C₂₀H₂₄F₂N₂O
Molecular Weight:346.42
Hs Code.:

Synonyms:C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

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Chemical Property of C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

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Technology Process of C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

There total 3 articles about C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 777833-33-7
(S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidine-2-carboxylic acid amide

: 183865-99-8
C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1021/jm960305h

Reference yield:

: 365-24-2
4,4'-difluorobenzhydryl alcohol

: 183865-99-8
C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / toluene

2: 32 percent / K₂CO₃ / toluene / 24 h / Heating

3: 93 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; In tetrahydrofuran; toluene;
DOI:10.1021/jm960305h

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 183865-99-8
C-((S)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-pyrrolidin-2-yl)-methylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / K₂CO₃ / toluene / 24 h / Heating

2: 93 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; toluene;
DOI:10.1021/jm960305h